607 Clausenamide, an alkaloid isolated from Clausena lansium , interacts directly with Ser663 of ALOX5, blocking the nuclear translocation of ALOX5, alleviating lipid peroxide accumulation and ferroptosis in dopaminergic neurons, significantly improving behavioral deficits in PD mouse models, and providing an attractive strategy for PD treatment
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Cysteine is a sulfhydryl group donor which is required for mitochondrial energy generation (for example, mitochondrial co-enzyme A (CoA-SH) requires a sulfhydryl group for its function), and is necessary for multiple cellular processes and reactions
These findings suggest that growth hormone therapy during childhood and/or adolescence may lead to a better metabolic profile in adults with PWS who have del15q, but not in those with mUPD, thus lessening the phenotypic impact of the deletion
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